#Supertab example full#

Many different characterization techniques to measure flow have been developed and correlated to the powder flow behavior in different processing units. This also explains why flow behavior (and ranking) of powders can be different between different measurement methods and applications. The forces that influence material flowability depend on the flow field and stress state as well as on external factors, like equipment design and material, temperature, and humidity. Flowability is the result of material physical properties and the equipment used for handling, storing or processing the material. Predicting how powder will flow into the dies is however not easy, as flowability is a complex, multidimensional property. The production capacity of a tablet press is directly determined by the rotation frequency of the die table and limited by powder flow into the dies. Because of powder flow limitations in this step, a slow-speed process that works well may not work at all when rates are increased. Weight variations in the final dosage form can occur when the flowability of the final formulation limits the separation of small quantities of powder from the larger mass of powder. In pharmaceutical processing, insufficient flow can lead to product quality failures, due to large weight or dosage variations. It determines for example whether bins can be used or hand scooping is required, to what extend product is scraped at the beginning or end of a run, and the allowable production rate of products. Flow is also relevant for manufacturing efficiency for batch processes. In a continuous manufacturing line for example, consistent and continuous flow through the system is a critical requirement for finished product quality. Often understanding powder behavior is crucial to properly design the process and equipment. Powders are used in many industries and in a broad range of processes and applications. This study also revealed that obtained insights on rheological behavior can be used to optimize agitator settings in a tableting machine.

The presence of fines between larger particles turned out to reduce the rheological index, which the authors explain by improved particle separation at more dynamic flow fields. Particle size distribution was identified as a main contributing factor to the rheological behavior of powders. A new parameter for rheological behavior was introduced, which is a measure for the change in dynamic cohesive index upon changes in flow field. In the current study, the rheological behavior was investigated for a wide range of excipients with a wide range of material properties. One of the challenges in mimicking the die filling process is the impact of rheological powder behavior as a result of differences in flow field in the feeding frame. Many flow characterization techniques are present, but so far only a few have shown to mimic the die filling process successfully. Use traditional methods to remove the Super Tab from the metal surface.With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies.

The Super Tab adapter can be unscrewed from the Super Tab base. To remove, slide the adapter out of T-nut on the corresponding slot on the K-Bar. Once this is accomplished, lifting and dent manipulation can begin. Taking care not to disrupt the tab’s glue bond, position the T-Nut of the super tab into the corresponding slot on the K-Bar. Slide in until a positive fit is achieved. Re-insert the threaded adapter. Carefully prepare the metal surface for glue pulling and adding adhesive to the face of the Super Tab.

#Supertab example full#

To take full advantage of this mechanism, begin by carefully removing the threaded bolt from the Super Tab. KECO’s K-Bar lifting system can also be configured for use with our Super Tab glue pulling tabs. Using the Super Tab adapter & Slide Hammer adapter, a high strength, mechanical joint can be achieved between the Super Tab and the K-Bar. The combination creates a robust, stable, and repeatable joint that allows the technician adjust lifting pressure and dent manipulation without additional focus on the tab stem.